Non-alcoholic fatty liver disease and psoriasis: So far, so near

Table 1 Role of adipocytokines in non-alcoholic fatty liver disease and psoriasis

	Adipocytokines	Psoriasis	NAFLD
Anti-inflammatory	Adiponectin	↓ Promotes anti-inflammatory cytokines	↓ Increase insulin-sensitivity
Pro-inflammatory	IL-6 TNF-α	↑ Keratinocyte proliferation ↑ (1) Keratinocyte proliferation; (2) Angiogenesis; and (3) Promotes expression of adhesion molecules; and (4) Increase pro-inflammatory cytokines	↑ Contributes to insulin-resistance ↑ Contributes to insulin-resistance; Increase hepatic fibrogenesis
	Leptin	↑ (1) Keratinocyte proliferation; (2) Promotes Th1 responses; and (3) Angiogenesis	↑ (1) Leptin-resistance; and (2) Contributes to hepatic fibrogenesis
	Resistin	↑ Increase pro-inflammatory cytokines	↑ (1) Contributes to insulin-resistance; and (2) Controversial data on NAFLD
	Visfatin	↑	Not altered in early stage; Protection toward liver injury (?); Negatively correlated to TNF-α
	Ghrelin	↑	↑

NAFLD: Non-alcoholic fatty liver disease.