Liver steatosis in hepatitis C patients

Figure 3 Simplified representation of the effect of steroid response element binding protein on lipid synthesis. Insulin promotes transcription of steroid response element binding protein (SREBP). In the endoplasmic reticulum, SREBP binds to SREBP cleavage-activating protein, a complex which moves to the Golgi apparatus, where the active N-terminal form of SREBP is formed by the sequential action of two proteases (S1P and S2P), and is finally translocated to the nucleus. SCAP: SREBP cleavage-activating protein; PUFA: Polyunsaturated fatty acid.