Skin toxicity predicts efficacy to sorafenib in patients with advanced hepatocellular carcinoma

doi:10.4254/wjh.v6.i9.670

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Retrospective Study

World J Hepatol. Sep 27, 2014; 6(9): 670-676
Published online Sep 27, 2014. doi: 10.4254/wjh.v6.i9.670

Table 1 Baseline patient characteristics n (%)

Variables	Number of patients
Gender	Male	30 (81)
Gender	Female	7 (19)
Age (yr)	> 70	19 (51)
Age (yr)	≤ 70	18 (49)
Child-pugh class	A	33 (89)
Child-pugh class	B	4 (11)
Etiology	HCV	20 (54)
	HBV	11 (30)
	Others	6 (16)
TNM stage	III	16 (43)
	IVa	8 (22)
	IVb	13 (35)
Previous therapies	Yes	31 (84)
Previous therapies	No	6 (16)
AFP (ng/mL)	> 100	20 (54)
AFP (ng/mL)	≤ 100	17 (46)
DCP (mAU/mL)^a	> 1000	20 (59)
DCP (mAU/mL)^a	≤ 1000	14 (41)
Initial dose of sorafenib (mg/d)	800	21 (57)
Initial dose of sorafenib (mg/d)	< 800	16 (43)
Nursing intervention	Yes	24 (65)
Nursing intervention	No	13 (35)

^aDCP values were not available for 3 cases; TNM: Tumor-Node-Metastasis staging system; AFP: α-fetoprotein; DCP: Des-gamma-carboxy prothrombin; HBV: Hepatitis B virus; HCV: Hepatitis C virus.

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Citation: Shomura M, Kagawa T, Shiraishi K, Hirose S, Arase Y, Koizumi J, Mine T. Skin toxicity predicts efficacy to sorafenib in patients with advanced hepatocellular carcinoma. World J Hepatol 2014; 6(9): 670-676
URL: https://www.wjgnet.com/1948-5182/full/v6/i9/670.htm
DOI: https://dx.doi.org/10.4254/wjh.v6.i9.670

Shomura M, Kagawa T, Shiraishi K, Hirose S, Arase Y, Koizumi J, Mine T. Skin toxicity predicts efficacy to sorafenib in patients with advanced hepatocellular carcinoma. World J Hepatol 2014; 6(9): 670-676 [PMID: 25276283 DOI: 10.4254/wjh.v6.i9.670]

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