Pictures of focal nodular hyperplasia and hepatocellular adenomas

Figure 2 Focal nodular hyperplasia microscopic typical features on Masson’s trichrome, glutamine synthase and CK7 immunostainings. A: Same patient as Figure 1C. Glutamine synthase (GS) immunostaining: typical aspect of focal nodular hyperplasia (FNH) with large anastomosed positive areas in a “map-like” pattern[11]. B-D: Woman born in 1969; abnormal liver function tests (GGT); ultrasound (US): nodule interpreted as a hemangioma, computed tomography scan and magnetic resonance imaging: FNH 8 cm, segment VIII with minor dilatation of the right biliary tree (compression by the tumor). Left lobectomy + segmentectomy VIII in 2002 (other nodule segment II: 0.5 cm). B, C: GS immunostaining: typical aspect of FNH with anastomosed positive areas often centered by veins (arrowhead) and at distance of fibrous bands (arrows). C and D are from 2 serial sections. D: CK7 immunostaining: ductular reaction at the periphery of fibrous bands. E, F: Same patient as Figure 1C. E: Masson’s trichrome - fibrous bands surrounding benign hepatocytic nodules of different sizes. F: CK7 immunostaining - prominent ductular reaction at the junction between parenchymal nodules and fibrous bands. Typical aspect of FNH.