Pediatric nonalcoholic fatty liver disease: A clinical and laboratory challenge

doi:10.4254/wjh.v2.i7.275

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World Journal of Hepatology

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1948-5182

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World J Hepatol. Jul 27, 2010; 2(7): 275-288
Published online Jul 27, 2010. doi: 10.4254/wjh.v2.i7.275

Table 1 Studies providing an estimate of nonalcoholic fatty liver disease in the pediatric population

Authors/year/country	Sample size (n)	Age range (yr)	Clinical characteristics	Criteria	Prevalence (%)
Tominaga et al/1995/Japan[4]	810	4-12	Population-based (Japan)	Ultrasound echogenicity	2.60
Strauss et al/2000/USA[5]	2450	12-18	Population-based (NHANES III)	Elevated ALT (> 30 U/L)	3.00
Park et al/2005/Korea[6]	1594	10-19	Population-based (Korean NHANES)	Elevated ALT (> 40 U/L)	3.20
Schwimmer et al/2006/USA[7]	742	2-19	Population-based (Autopsy data, San Diego County)	Liver histology with ≥ 5% hepatocytes containing fat	9.60
Tominaga et al/2009/Japan[8]	846	6-15	Population-based (Japan)	Ultrasound echogenicity	4.40
Alavian et al/2009/Iran[9]	966	7-18	Population-based (Iran)	Ultrasound echogenicity	7.10
Tazawa et al/1997/Japan[10]	310	6-11	Obese cohort (% IBW/height over 120)	Elevated ALT (> 30 U/L)	24.00
Franzese et al/1997/Italy[11]	72	4-15	Obese cohort (% IBW/height over 120)	Ultrasound echogenicty	53.00
Guzzaloni et al/2000/Italy[12]	375	8-16	Obese cohort (BMI > 2 SD for chronologic age)	Ultrasound echogenicity	42.00
Chan et al/2004/China[13]	84	7-18	Obese cohort (BMI > 95^th percentile)	Ultrasound echogenicty	77.00
Flores-Calderon et al/2005/Mexico[14]	80	8-10	Overweight (> 85^th) and obese (> 95^th percentile) cohort	Elevated ALT (> 40 U/L)	42.00
Louthan et al/2005/USA[15]	181	4-17	Obese cohort (BMI > 95^th percentile)	Elevated ALT (> 40 U/L)	8.00
Quiros-Tejeira et al/2007/USA[16]	517	4-19	Obese cohort (BMI > 95^th percentile)	Elevated ALT (> 97.5^th percentile for age-and sex-specific reference values)	24.00
Rocha et al/2009/Brazil[17]	175	12-15	Obese cohort (WC > 75^th percentile)	Ultrasound echogenicity	1.70
Denzer et al/2009/Germany[18]	532	8-19	Obese cohort (BMI > 90^th percentile)	Ultrasound echogenicity	28.00
Papandreou et al/2009/Greece[19]	43	9-13	Obese cohort	Ultrasound echogenicity	42.00

IBW: ideal body weight; BMI: body mass index; NHANES: national health and nutrition examination survey; ALT: alanine aminotransferase.

Citation: Pacifico L, Poggiogalle E, Cantisani V, Menichini G, Ricci P, Ferraro F, Chiesa C. Pediatric nonalcoholic fatty liver disease: A clinical and laboratory challenge. World J Hepatol 2010; 2(7): 275-288
URL: https://www.wjgnet.com/1948-5182/full/v2/i7/275.htm
DOI: https://dx.doi.org/10.4254/wjh.v2.i7.275