Discussion on the effect of Honghua Qinggan Shisanwei Wan on regulating macrophage polarization and alleviating liver injury

Figure 8 The effect of Honghua Qinggan Shisanwei Wan on the secretion levels of M1/M2 phenotype-related factors in macrophages. A: The inhibitory effect of Honghua Qinggan Shisanwei Wan on the expression of inducible nitric oxide synthase, a marker of M1-type macrophages, and the secretion of pro-inflammatory factors; B: The promoting effect of Honghua Qinggan Shisanwei Wan on the expression of YM-1, a marker of M2-type macrophages, and the secretion of anti-inflammatory factors. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001, NS: Not significant. TNF-α: Tumor necrosis factor-α; Con: Control; HHQG: Honghua Qinggan Shisanwei Wan; IL: Interleukin; CCL2: C-C motif chemokine ligand 2; iNOS: Inducible nitric oxide synthase; TGF: Transforming growth factor; CX3CR1: C-X3-C motif chemokine receptor 1; Arg1: Arginase1.