Discussion on the effect of Honghua Qinggan Shisanwei Wan on regulating macrophage polarization and alleviating liver injury

Figure 3 Protective effect of Honghua Qinggan Shisanwei Wan against carbon tetrachloride-induced liver injury in mice. A: Gene Ontology enrichment of differential gene in model group and tr Honghua Qinggan Shisanwei Wan (HHQG) hepatoprotective group on the 2^nd day; B: Kyoto Encyclopedia of Genes and Genomes enrichment of differential gene in model group and HHQG hepatoprotective group on the 2^nd day; C: Heatmap of differentially expressed genes associated with macrophage polarization. Carbon tetrachloride (CCl₄) was the model group, which included three different samples: CCl₄-1, CCl₄-2, and CCl₄-3; HHQG was the HHQG group, which included three different samples: HHQG-1, HHQG-2, and HHQG-3. PPAR: Peroxisome proliferator-activated receptor; HIF: Hypoxia-inducible factor; MAPK: Mitogen-activated protein kinase; GTP: Guanosine triphosphate; BP: Biological process; CC: Cellular component; MF: Molecular function; CCl₄: Carbon tetrachloride; HHQG: Honghua Qinggan Shisanwei Wan.