Association between insulin and liver function tests, liver disease and cirrhosis in population-based cohorts with long term follow-up

doi:10.4254/wjh.v17.i6.107160

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Hepatol. Jun 27, 2025; 17(6): 107160
Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.107160

Table 3 Multivariable Cox regression analysis with risk factors for elevated liver function tests at follow-up

	Main analysis HR (95%CI)	Sensitivity analysis HR (95%CI)
Insulin (mIU/L)	1.02 (1.00-1.03)^a	1.02 (1.01-1.04)^b
Ethanol (10 g/day)	1.15 (1.05-1.25)^b	1.15 (1.04-1.26)^b
Leisure time physical activity (moderate/regular vs sedentary lifestyle)	0.62 (0.45-0.84)^b	0.60 (0.43-0.82)^b
Coffee (cups per day)	0.92 (0.87-0.97)^b	0.94 (0.89-0.99)^a

^aP < 0.05.

^bP < 0.01.

Adjusted for sex and age. Main analysis: 234 events among total n = 1595. Sensitivity analysis (exclusion of prevalent cases with elevated liver function tests or liver disease): 215 events among total n = 1530. HR: Hazard ratio.

Citation: Schult A, Mehlig K, Svärdsudd K, Wallerstedt S, Björkelund C, Hansson PO, Zetterberg H, Kaczynski J. Association between insulin and liver function tests, liver disease and cirrhosis in population-based cohorts with long term follow-up. World J Hepatol 2025; 17(6): 107160
URL: https://www.wjgnet.com/1948-5182/full/v17/i6/107160.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i6.107160