Cytokeratin 18 fragment is associated with steatosis-associated fibrosis estimator score and lipid in patients with steatotic liver disease

Figure 1 Relationship between cytokeratin 18 fragment and clinical factors. A: Aspartate aminotransferase (AST), alanine aminotransferase (ALT), ferritin, triglycerides (TG), high-density lipoprotein (HDL), and hemoglobin A1c (HbA1c), which were noted to correlate with cytokeratin 18 fragment (CK18F), were used in a multiple regression analysis. AST, ALT, and triglyceride (TG) were associated with CK18F; B: In the combined Figure 1A, TG and HDL were changed to TG/HDL and the same analysis was performed. AST, ALT, and TG/HDL were associated with CK18F; C: Multiple logistic regression analysis for CK18F > 260 U/L (high CK18F). In non-invasive tests, steatosis-associated fibrosis estimator (SAFE) score and FibroScan-aspartate aminotransferase (FAST) were associated with CK18F. SAFE score was divided as follows: (1) High (> 100); (2) Moderate (0-100); and (3) Low (< 0). FAST was divided as follows: (1) High (> 0.35); and (2) Low (< 0.35). Low-risk, moderate-risk, and high-risk (LMH) SAFE and low-risk and high-risk (LMH) FAST corresponded with CK18F.