Assessment of circulating levels of microRNA-326, microRNA-424, and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians

doi:10.4254/wjh.v14.i8.1562

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Aug 27, 2022 (publication date) through May 2, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Aug 27, 2022; 14(8): 1562-1575
Published online Aug 27, 2022. doi: 10.4254/wjh.v14.i8.1562

Table 4 Diagnostic performance of the studied miRNAs

	Cut off	Sensitivity	Specificity	PPV	NPV	Accuracy	AUC	95%CI	P value
miRNA-326	> 1.165	0.971	0.52	0.85	0.867	0.853	0.784	67.7-89.1	< 0.001^b
miRNA-511	< 2.063	0.714	0.6	0.833	0.429	0.684	0.654	53.1-77.7	0.01^a
miRNA-424	> 2.462	0.829	0.48	0.817	0.5	0.737	0.559	40.4-71.5	0.4

PPV: Positive predictive value; NPV: Negative predictive value; AUC: Area under curve; 95%CI: 95%Confidence interval.

^aP value < 0.05 is significant.

^bP value < 0.01 is highly significant.

Citation: Youssef SS, Elfiky A, Nabeel MM, Shousha HI, Elbaz T, Omran D, Marie MS, Elzahry MA, Abul-Fotouh A, Hashem A, Guda MF, Abdelaziz AO. Assessment of circulating levels of microRNA-326, microRNA-424, and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians. World J Hepatol 2022; 14(8): 1562-1575
URL: https://www.wjgnet.com/1948-5182/full/v14/i8/1562.htm
DOI: https://dx.doi.org/10.4254/wjh.v14.i8.1562