Immunological classification of hepatitis B virus-positive hepatocellular carcinoma by transcriptome analysis

Figure 1 Identification of immune-specific subtypes of hepatitis B virus + hepatocellular carcinoma by clustering analysis. A: Based on the enrichment scores of 23 immune signatures, hierarchical clustering identifies two immune-specific subtypes of hepatitis B virus (HBV) + hepatocellular carcinoma (HCC): Imm-H and Imm-L, with high and low immunity, respectively, consistently in three datasets; B: Prediction of the immune-specific subtypes of HBV+ HCC by the Random Forest algorithm using the 23 immune signatures as attributes. The 10-fold cross-validation results in the training set and classification results in test sets are shown.