Aceclofenac-induced hepatotoxicity: An ameliorative effect of Terminalia bellirica fruit and ellagic acid

doi:10.4254/wjh.v12.i11.949

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 27, 2020; 12(11): 949-964
Published online Nov 27, 2020. doi: 10.4254/wjh.v12.i11.949

Table 3 Effect of Terminalia bellirica fruit extracts and ellagic acid on antioxidant markers in liver tissue homogenate of aceclofenac treated rats

Groups	MDA (nmol/mg protein)	SOD (U/mg protein)	Catalase (U/mg protein)
Group I	2.68 ± 0.08	31.09 ± 0.71	8.45 ± 0.17
Group II	18.63 ± 1.43^a	12.04 ± 1.49^a	3.21 ± 0.84^a
Group III	4.50 ± 0.18^b1	29.11 ± 0.35^b1	7.59 ± 0.41^b1
Group IV	6.74 ± 0.14^b1	27.24 ± 0.57^b1	7.19 ± 0.37^b1
Group V	12.28 ± 0.12^b2	19.80 ± 0.62^b2	5.77 ± 1.19^b2
Group VI	9.46 ± 0.19^b1	21.15 ± 0.49^b2	6.23 ± 0.92^b2

Group-I: Control rats; Group-II: Aceclofenac (ACF) treated rats; Group-III: ACF + Silymarin treated rats; Group-IV: ACF + Ellagic acid treated rats; Group-V: ACF + Aqueous extract treated rats; Group-VI: ACF + Ethyl acetate extract treated rats. Each value is expressed as mean ± SD (n = 5). Silymarin was used as a positive control. SOD: Superoxide dismutase; MDA: Malondialdehyde.

^aRepresents a significant difference compared with the control (¹P < 0.0001).

^bRepresents a significant difference compared with group II.

^b1P < 0.0001.

^b2P < 0.005.

Citation: Gupta A, Pandey A. Aceclofenac-induced hepatotoxicity: An ameliorative effect of Terminalia bellirica fruit and ellagic acid. World J Hepatol 2020; 12(11): 949-964
URL: https://www.wjgnet.com/1948-5182/full/v12/i11/949.htm
DOI: https://dx.doi.org/10.4254/wjh.v12.i11.949