Aceclofenac-induced hepatotoxicity: An ameliorative effect of Terminalia bellirica fruit and ellagic acid

Table 1 Effect of Terminalia bellirica fruit extracts and ellagic acid on body weight and liver weight of aceclofenac treated rats

Groups	Body weight, change (%)	Absolute liver, weight (g)	Relative liver, weight (%)
Group I	18.83 ± 1.15	4.62 ± 0.16	2.85 ± 0.29
Group II	-20.50 ± 6.87a	6.56 ± 0.41a	3.95 ± 1.29a
Group III	-09.17 ± 3.78b	4.82 ± 0.19b	3.05 ± 0.35b
Group IV	-11.06 ± 3.77b	5.17 ± 0.87b	3.13 ± 0.46b
Group V	-18.50 ± 6.26b	5.70 ± 1.09b	3.44 ± 0.58b
Group VI	-14.83 ± 3.21b	5.03 ± 0.95b	3.21 ± 0.64b

Group I: Control rats; Group II: Aceclofenac (ACF) treated rats; Group III: ACF + Silymarin treated rats; Group IV: ACF + Ellagic acid treated rats; Group V: ACF + Aqueous extract treated rats; Group VI: ACF + Ethyl acetate extract treated rats. Each value is expressed as mean ± SD (n = 5). Silymarin was used as a positive control.

^aRepresents a significant difference compared with the control (^aP < 0.0001).

^bRepresents a significant difference compared with group II (^bP < 0.005).