Is porto sinusoidal vascular disease to be actively searched in patients with portal vein thrombosis?

Table 2 Predisposing causes of portal vein thrombosis

Systemic prothrombotic conditions	Recommended checks
Inherited	Resistance to activated C protein/molecular biology for
Factor V Leiden	G1691A polymorphism
Prothrombin gene mutation	Molecular biology for G20210A polymorphism
Protein C, protein S and antithrombin deficiency	Ratio with F II, V, VII or X after correction for vitamin K deficiency; family survey (recommended)
Acquired
Antiphospholipid syndrome	Anticardiolipin ELISA; LLAC
Myeloproliferative neoplasm (MPN)	JAK2 and CALR mutations; osteomidullary biopsy
Paroxysomal nocturnal hemoglobinuria	Flow cytometry (deficient cells of CD55 and CD59)
Oral contraceptive use	Anamnesis
Obesity	BMI > 30 kg/m2
CMV infection	CMV IgG, CMV IgM
Pregnancy	Beta-HCG, anamnesis
Celiac disease	Anti-transglutaminase IgA/IgG
Local prothrombotic conditions	Anamnesis and radiological examination
Surgery and trauma
Umbilical cannulation
Splenectomy, cholecystectomy
Hepatic resection
Abdominal trauma
Bariatric surgery
Portosystemic shunts including TIPS	Anamnesis and radiological examination
Inflammatory and infectious diseases
Neonatal omphalitis
Appendicitis, diverticulitis, pancreatitis
Inflammatory bowel disease
Cholecystitis, cholangitis
Other
Cirrhosis
Porto sinusoidal vascular liver disease

LLAC: Lupus-like anticoagulant; ELISA: Enzyme-linked immunosorbent assay; BMI: Body mass index; CMV, Cytomegalovirus; HCG: Human chorionic gonadotropin; Ig: Immunoglobulin; TIPS: Transjugular portosystemic intrahepatic shunt.