Survival outcomes of liver transplantation for hepatocellular carcinoma in patients with normal, high and very high preoperative alpha-fetoprotein levels

Table 2 Comparison of the two subgroups, Group D and Group E

	Group D (n = 180)	Group E (n = 70)	P value
Age (yr)	56 (38-67)	53.5 (3-72)	0.017
Male:Female	150:30	59:11	0.855
Diagnosis:
Cirrhosis
Cryptogenic	4	1
Hepatitis B	136	45
Hepatitis C	19	10
Alcoholic	1	1
Hepatitis B + C	1	2
Alcoholic + hepatitis C	1	1
Alcoholic + hepatitis B	1	0
Autoimmune	1	0
Wilson's disease	0	0
Preoperative MELD score	12 (6-35)	12 (6-43)	0.972
Waiting time (d)	58.5 (1-2735)	32 (1-1874)	0.183
Blood transfusion (units)	3 (0-56)	4(0-32)	0.988
Fresh frozen plasma transfusion (units)	6 (0-30)	6 (0-22)	0.798
Platelet transfusion (units)	6 (0-30)	8 (0-32)	0.708
Operation time (min)	654 (333-1110)	716.5 (300-1273)	0.151
Cold ischemic time (min)	137.5 (60-652)	127.5 (66-633)	0.195
Warm ischemic time (min)	51 (25-108)	53 (28-93)	0.308
Hospital stay (d)	15.5 (0-132)	16 (7-48)	0.497
Intensive care unit stay (d)	3 (0-42)	3 (2-30)	0.806
Follow-up (mo)	87.2 (0.0-210.8)	75.4 (3.8-206.8)	0.173
Hospital mortality	4 (2.2%)	0	0.486
LDLT: DDLT	112:68	54:16	0.025
Explant Milan Within:Beyond	116:60	39:30	0.170
Explant UCSF Within:Beyond	135:41	49:20	0.354
No. of tumor in explant	1.5 (1-multiple)	1 (1-20)	0.551
Largest size of tumor in explant (cm)	2.85 (0.90-7.00)	3.5 (0.25-19.5)	0.017
Differentiation			0.0001
Well	59	11
Moderate	91	41
Poor	6	10
Undifferentiated	0	2
Unknown	20	5
Vascular permeation			0.014
No	124	35
Yes	48	31
Unknown	4	3
Graft loss	37 (20.6%)	24 (34.3%)	0.023
Patient status Alive:Dead	143:37	47:23	0.041
Graft survival, yr			0.024
1	95.00%	94.30%
3	87.20%	81.40%
5	83.80%	72.30%
Patient survival, yr			0.045
1	95.60%	95.70%
3	87.20%	82.90%
5	83.80%	73.80%
Disease-free survival, yr			0.006
1	91.10%	84.30%
3	85.00%	75.70%
5	82.20%	70.00%
Postoperative early complication by Clavien grading			0.798
No	90	38
I	35	17
II	16	4
IIIA	19	6
IIIB	11	3
IVA	6	2
IVB	0	0
V	3	0