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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Mar 27, 2015; 7(3): 593-599
Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.593
Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.593
Prevention of hepatocellular carcinoma: Focusing on antioxidant therapy
Koji Miyanishi, Toshifumi Hoki, Shingo Tanaka, Junji Kato, Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Author contributions: Miyanishi K contributed to the review design and drafting the manuscript; Hoki T and Tanaka S contributed to drafting the manuscript; Kato J contributed to drafting the manuscript and revision.
Conflict-of-interest: The authors have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Koji Miyanishi, MD, PhD, Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-Ku, Sapporo 060-8543, Japan. miyako@sapmed.ac.jp
Telephone: +81-11-6112111 Fax: +81-11-6127987
Received: August 22, 2014
Peer-review started: August 23, 2014
First decision: September 28, 2014
Revised: October 20, 2014
Accepted: December 29, 2014
Article in press: December 29, 2014
Published online: March 27, 2015
Peer-review started: August 23, 2014
First decision: September 28, 2014
Revised: October 20, 2014
Accepted: December 29, 2014
Article in press: December 29, 2014
Published online: March 27, 2015
Core Tip
Core tip: Among treatment options where it would be expected that anti-inflammatory activity plays a role in their confirmed efficacy for chronic hepatitis, iron depletion therapy, glycyrrhizin, ursodeoxycholic acid, Sho-Saiko-To, and vitamin E can all be considered antioxidant therapies. In chronic liver diseases, it has been demonstrated that antioxidant therapy may potentially be effective for suppressing inflammation and liver fibrosis and expected to prevent carcinogenesis.