Ability of human umbilical cord mesenchymal stem cells to repair chemotherapy-induced premature ovarian failure

Table 1 The number of mice in the normal oestrus cycle at each time point in each group

Groups	1-15 d	16-30 d	31-45 d	46-60 d
Negative control group	20	15	10	5
Model group	0	0	0	0
hUCMSC group	0	7	4	3
Positive control group	0	6	4	4

hUCMSC: Human umbilical cord mesenchymal stem cell.

Table 2 Comparison of ovarian weight in each group at each time point

Items	After transplantation
	1 d	15 d	30 d	45 d	60 d
Negative control group	36.67 ± 0.68	36.97 ± 0.32	37.45 ± 0.35	34.86 ± 0.43	38.13 ± 0.35
Model group	23.19 ± 0.98	20.23 ± 0.49	18.30 ± 0.28	18.02 ± 0.41	17.25 ± 0.28
hUCMSC group	21.19 ± 0.65	19.54 ± 0.27	21.77 ± 0.48	23.11 ± 0.38	24.28 ± 0.48
Positive control group	22.50 ± 0.62	19.30 ± 0.37	24.53 ± 0.93	27.64 ± 0.34	28.06 ± 0.93
P value	P < 0.05

hUCMSC: Human umbilical cord mesenchymal stem cell.

Table 3 E2 concentration of each group at each time point

Items	Before transplantation	After transplantation
		1 d	15 d	30 d	45 d	60 d
Negative control group	56.94 ± 4.43	51.42 ± 2.35	53.99 ± 2.73	53.43 ± 3.26	52.04 ± 1.65	55.43 ± 1.57
Model group	55.23 ± 4.35 (P = 0.147)	35.41 ± 2.25	28.32 ± 1.51	24.86 ± 0.90	22.16 ± 1.25	18.99 ± 1.40
hUCMSC group	55.83 ± 3.35 (P = 0.325)	37.84 ± 1.69	38.33 ± 1.79	35.04 ± 2.31	35.12 ± 1.47	34.10 ± 1.42
Positive control group	55.03 ± 3.43 (P = 0.357)	37.34 ± 1.86	37.80 ± 1.83	36.86 ± 2.09	36.86 ± 1.11	37.08 ± 1.47
P value	P > 0. 05

hUCMSC: Human umbilical cord mesenchymal stem cell.

Table 4 Follicle-stimulating hormone concentration of each group at each time point

Items	Before transplantation	After transplantation
		1 d	15 d	30 d	45 d	60 d
Negative control group	8.61 ± 0.03	9.25 ± 0.35	8.64 ± 0.56	9.27 ± 0.36	8.93 ± 0.26	9.11 ± 0.10
Model group	8.76 ± 0.17 (P = 0.19)	18.33 ± 0.79	20.36 ± 0.74	22.38 ± 1.05	24.26 ± 1.15	25.19 ± 0.96
hUCMSC group	8.70 ± 0.38 (P = 0.93)	19.44 ± 1.23	14.07 ± 0.53	15.52 ± 0.57	18.22 ± 1.14	18.55 ± 0.66
Positive control group	8.66 ± 0.45 (P = 0.10)	18.5 ± 0.31	12.50 ± 0.63	12.39 ± 0.03	13.50 ± 1.04	14.28 ± 0.64
P value	P > 0. 05

hUCMSC: Human umbilical cord mesenchymal stem cell.