Immunomodulatory oligonucleotide IMT504: Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy

doi:10.4252/wjsc.v9.i3.45

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Mar 26, 2017; 9(3): 45-67
Published online Mar 26, 2017. doi: 10.4252/wjsc.v9.i3.45

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Figure 2 Effect of IMT504 or mesenchymal stem cell treatment on the development of mechanical allodynia in rats. Sciatic nerve crush induced a significant decrease in paw withdrawal threshold to the von Frey filaments. It is noticeable that the administration of either IMT504 or MSCs prevents the development of allodynia. Experimental details are described in Coronel et al[343]. MSC: Mesenchymal stem cell.

Citation: Zorzopulos J, Opal SM, Hernando-Insúa A, Rodriguez JM, Elías F, Fló J, López RA, Chasseing NA, Lux-Lantos VA, Coronel MF, Franco R, Montaner AD, Horn DL. Immunomodulatory oligonucleotide IMT504: Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy. World J Stem Cells 2017; 9(3): 45-67
URL: https://www.wjgnet.com/1948-0210/full/v9/i3/45.htm
DOI: https://dx.doi.org/10.4252/wjsc.v9.i3.45