Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance

Figure 4 Transition from randomly orientated patches to radial stripes in corneal epithelia of different types of mosaic mice between 3 wk and adulthood. A and B: β-gal staining in XLacZ X-inactivation mosaics[27]; C and D: Green fluorescent protein (GFP) fluorescence in CAG-GFP transgenic mosaics[⁷⁷]; E and F: GFP fluorescence in corneal epithelium after transfecting conceptuses with lentiviral vectors encoding GFP at embryonic day 9 or 10[⁷⁹]. Photographs (A and D) are reproduced from Developmental Dynamics[²⁷] with kind permission of John Wiley and Sons, (C and D) are reproduced from Molecular Vision[⁷⁷] with kind permission of the authors and editors, and photographs (E and F) are reproduced from Molecular Therapy[⁷⁹] with kind permission of the authors and the Nature Publishing Group. This combination of photographs was first published by Mort et al[¹⁸].