Mitochondria as therapeutic targets for cancer stem cells

Table 2 Mitochondrial features of cancer stem cells according to cancer origin

Cancer origin	Mitochondria features			Energy metabolism of CSC	Target/drug for CSCs	Ref.
	Feature	CSC	Non-CSC
Breast	Glucose uptake	High	Low	OXPHOS		[68]
	ATP contents	High	Low
	OCR	High	Low
	Lactate production	Low	High
	Membrane potential	High	Low
Glioma	Glucose consumption	Low	High	OXPHOS		[66]
	ATP contents	High	Low
	Lactate production	Low	High
	OCR	High	Low	OXPHOS	IMP-2	[67]
	ATP contents	High	Low
Leukemia	ROS	Low	High	Low glycolysis	Bcl-2/	[63]
	Proliferation rate	Slow	Fast	Low OXPHOS	ABT263
	OCR	Low	High
	Lactate production	Low	High
	ATP contents	Low	High
Lung	Glucose consumption	Low	High			[62]
	OCR	Low	High
	ROS level	Low	High
	ATP contents	Low	High
	Membrane potential	High	Low
	Mitochondrial DNA	Low	High
Ovarian					NV-128	[65]
	ROS	High	Low	OXPHOS		[64]
	Membrane potential	High	Low
	ATP contents	High	Low
	Glucose deprivation	Resist	Sensitive

CSC: Cancer stem cell; OCR: Oxygen consumption rate; ROS: Reactive oxygen species; OXPHOS: Oxidative phosphorylation; ABT263: Bcl-2 inhibitor; NV-128: Isoflavone derivative (play a role as inhibitor of mitochondrial function); IMP-2: Insulin-like growth factor 2 mRNA-binding protein 2.