Therapeutic strategies for intervertebral disc degeneration: Extracellular vesicles and microRNAs derived from mesenchymal stem cells

doi:10.4252/wjsc.v17.i7.107212

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Jul 26, 2025 (publication date) through Jul 27, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jul 26, 2025; 17(7): 107212
Published online Jul 26, 2025. doi: 10.4252/wjsc.v17.i7.107212

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Figure 1 Schematic diagram of the effects of mesenchymal stem cells and extracellular vesicles on disc degeneration. Mesenchymal stem cells are initially isolated and cultured from tissue samples, and during culture, extracellular vesicles are generated in the medium, collected, isolated and purified. Resuspended extracellular vesicles are delivered to degenerating discs via intradiscal injection. MSC: Mesenchymal stem cell; NPC: Nucleus pulposus cell; ECM: Extracellular matrix.

Citation: Lim YJ, Seo MS, Park S, Lee GW. Therapeutic strategies for intervertebral disc degeneration: Extracellular vesicles and microRNAs derived from mesenchymal stem cells. World J Stem Cells 2025; 17(7): 107212
URL: https://www.wjgnet.com/1948-0210/full/v17/i7/107212.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i7.107212