MiR-126 regulates the effect of mesenchymal stem cell vascular repair on carotid atherosclerosis through MAPK/ERK signaling pathway

Figure 6 Enzyme-linked immunosorbent assay to detect the effect of miR-126 mimic on the levels of vascular endothelial growth factor and basic fibroblast growth factor in mesenchymal stem cells. A: The changes in the concentration of vascular endothelial growth factor (VEGF) under different treatment conditions; B: The changes in the concentration of basic fibroblast growth factor (bFGF) under different treatment conditions. The up-regulation of miR-126 significantly increased VEGF and bFGF secretion, whereas the down-regulation of miR-126 led to a marked decrease in the secretion of both VEGF and bFGF. Data are presented in mean ± SD and differences between groups were statistically calculated using one-way ANOVA. ^aP < 0.01. NC: Negative control; VEGF: Vascular endothelial growth factor; bFGF: Basic fibroblast growth factor.