MiR-126 regulates the effect of mesenchymal stem cell vascular repair on carotid atherosclerosis through MAPK/ERK signaling pathway

Figure 5 The complementary pairing between microRNA sequences and their target gene 3’-untranslated region. A: The seed sequence of rno-miR-126a-5p is fully complementary to the 3’-untranslated region (3’UTR) of sprouting-related protein 1 (SPRED1) and phosphatidylinositol 3-kinase regulatory subunit 2 (PIK3R2); B: The seed sequence of rno-miR-126b is partially complementary to the 3’UTR of SPRED1 and PIK3R2, with some mismatches in the binding sites; C: The seed sequence of rno-miR-126a-3p shows partial complementary pairing with the 3’UTR of SPRED1 and PIK3R2, including additional mismatches in the PIK3R2 binding site. Data from the RNAhybrid database. 3’UTR: 3’-untranslated region; SPRED1: Sprouting-related protein 1; PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit 2.