Fibro-adipogenic progenitors prevent skeletal muscle degeneration at acute phase upon tendon rupture in a murine tibialis anterior tenotomy model

Figure 6 The progression of muscle atrophy after tendon rupture in fibro-adipogenic progenitor-depleted mice. A: The hematoxylin and eosin staining results of the tibialis anterior muscle at 0 day, 1 week, and 6 weeks after tibialis anterior tenotomy (TAT) in PdgfraCre^ERT::Rosa^DTA mice induced with Tamoxifen or corn oil; B: The statistical analysis of average myofiber cross-sectional area which represents the severity of muscle atrophy; C: The FBXO32 immunohistochemistry staining results of the tibialis anterior muscle at 0 day, 1 week, and 6 weeks after TAT in PdgfraCre^ERT::Rosa^DTA mice induced with Tamoxifen or corn oil; D: The statistical analysis of the area fraction of positive stained area which represents the tendency of muscle atrophy (^aP < 0.05, compared to control group). TAT: Tibialis anterior tenotomy.