Reduced NRF2/Mfn2 activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells in hypertrophic obese mice

doi:10.4252/wjsc.v17.i6.104367

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Jun 26, 2025 (publication date) through Jun 29, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jun 26, 2025; 17(6): 104367
Published online Jun 26, 2025. doi: 10.4252/wjsc.v17.i6.104367

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Figure 7 Patterns of adipose-derived mesenchymal stem cell senescence. The decreased transcriptional activity of nuclear factor erythroid-derived 2 (NRF2) in the mitofusin-2 (Mfn2) gene region in adipose-derived mesenchymal stem cells (ASCs) leads to MFN2 deficiency and binding immunoglobulin protein (BIP) instability, which promotes endoplasmic reticulum (ER) stress and cell senescence. Knocking down Nrf2 or Mfn2 reduces the therapeutic efficacy of ASC transplantation.

Citation: Fang J. Reduced NRF2/Mfn2 activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells in hypertrophic obese mice. World J Stem Cells 2025; 17(6): 104367
URL: https://www.wjgnet.com/1948-0210/full/v17/i6/104367.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i6.104367