Reduced NRF2/Mfn2 activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells in hypertrophic obese mice

Figure 6 Nuclear factor erythroid-derived 2 or mitofusin-2 knockdown impair the therapeutic effect of adipose-derived mesenchymal stem cell transplantation. A and B: Body weight and blood glucose of control, obesity mice transplanted with phosphate buffered saline and obesity mice transplanted with short hairpin RNA (shRNA) against nuclear factor erythroid-derived 2 (shNrf2) and shRNA against mitofusin-2 (shMfn2) young adipose-derived mesenchymal stem cells (n = 6); C and D: Glucose tolerance test and insulin tolerance test of each group after 8 weeks of transplantation (n = 6); E and F: Hemoglobin A1c (HbA1C) and insulin enzyme linked immunosorbent assay detection of each group after 8 weeks of transplantation (n = 3). ^aP < 0.05; ^bP < 0.01.