Circular RNAs inducing the osteogenic differentiation of dental mesenchymal stem cells via microRNA sponging

doi:10.4252/wjsc.v17.i5.101638

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May 26, 2025 (publication date) through May 29, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. May 26, 2025; 17(5): 101638
Published online May 26, 2025. doi: 10.4252/wjsc.v17.i5.101638

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Figure 1 Diagrammatic of the biogenesis and sponging function of circular RNAs. Circular RNAs (circRNAs) are generated from pre-mRNAs. A loop structure is formed through back-splicing driven by the pairing of intronic complementary sequences. CircRNA is eventually formed by removing the intron sequences in the loop structure. CircRNAs sponge microRNAs to decrease their availability to bind and inhibit target mRNAs, leading to the expression of the target mRNAs. circRNA: Circular RNAs.

Citation: Jiang YS, Wei WS, Xie DT, Guo G. Circular RNAs inducing the osteogenic differentiation of dental mesenchymal stem cells via microRNA sponging. World J Stem Cells 2025; 17(5): 101638
URL: https://www.wjgnet.com/1948-0210/full/v17/i5/101638.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i5.101638