miR-3682-3p directly targets FOXO3 and stimulates tumor stemness in hepatocellular carcinoma via a positive feedback loop involving FOXO3/PI3K/AKT/c-Myc

Figure 6 HBx induces miR-3682-3p expression, thereby enhancing the cancer stem cell-like properties of hepatocellular carcinoma cells. A and B: The levels of miR-3682-3p after the overexpression and silencing of HBx were detected by RT-qPCR; C and D: RT-qPCR and western blot analysis of the effect of HBx on stemness markers. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. Experiments were repeated three times. NC: Negative control.