Rat model of anal sphincter injury and two approaches for stem cell administration

Table 1 Functional studies (anal manometry)

	Number of contractions	Frequency, n /min	Duration in s	Time to max in s	Peaks number, n	Range of mmHg	AUC
Preoperative
Number	36	36	36	36	36	36	36
Mean	19.489	1.6980	26.674752	8.882553	12.5323	25.9462	4884.9013
Standard deviation	7.1593	0.57698	6.6690300	2.9265056	3.52514	16.68935	3181.86004
Minimum	9.0	0.91	13.0000	4.2667	7.33	6.27	1227.46
Maximum	50.0	4.17	41.2800	15.6333	21.67	111.93	15790.69
Postoperative
Number	36	36	4	4	4	4	32
Mean	0.535	0.0446	26.425000	9.056250	7.5000	12.1950	418.2139
Standard deviation	1.5016	0.12513	5.8105507	4.2522727	2.48328	2.09572	361.06246
Minimum	0	0.00	20.4000	6.0750	5.00	10.39	12.91
Maximum	6.0	0.50	31.6000	15.1500	10.50	15.21	1610.80

A descriptive analysis is presented. In the first two columns, total number of contractions (defined as a rise higher than 10 mmHg) and their frequency are presented (studied within the 12-min selection). The following four columns focus on contraction characteristics: contraction duration, time to reach maximum from the beginning, number of twitches in each contraction, and range (maximum minus minimum). These values were calculated by selecting the six best contractions on each registry. Finally, the area under the pressure vs time curve (-AUC- calculated with the 12-min selection) values are presented. All of these variables are presented in basal (preoperative) and postoperative conditions.