Intestinal stem cells and celiac disease

doi:10.4252/wjsc.v6.i2.213

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Apr 26, 2014 (publication date) through May 16, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Apr 26, 2014; 6(2): 213-229
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.213

Intestinal stem cells and celiac disease

Anna Chiara Piscaglia

Anna Chiara Piscaglia, Endoscopy and Gastroenterology Unit, State Hospital-Republic of San Marino, 47893 Borgo Maggiore, Repubblica di San Marino

Author contributions: Piscaglia AC designed and wrote this manuscript.

Correspondence to: Anna Chiara Piscaglia, MD, PhD, Endoscopy and Gastroenterology Unit, State Hospital-Republic of San Marino, Via Scialoja 20, 47893 Borgo Maggiore, Repubblica di San Marino. annachiarapiscaglia@hotmail.com

Telephone: +39-347-1015909

Received: October 30, 2013
Revised: March 1, 2014
Accepted: March 11, 2014
Published online: April 26, 2014

Core Tip

Core tip: The intestinal epithelium has a high turnover rate since most of the epithelial cells are replaced every 3 to 5 d. This renewal is driven by intestinal stem cells residing within the crypt base at the origin of the crypt-to-villus hierarchical migratory pattern. Many aspects of the pathogenesis of celiac disease have been elucidated over the last years regarding the interactions among genetic and immunological factors, intestinal barrier and gut microbiota. Conversely, little is known about intestinal stem cell modulation and deregulation in celiac disease. The current knowledge regarding celiac disease and intestinal stem cells, and the potential role of stem cells in the development and treatment of the disease are summarized.

“Enthusiasm is that temper of the mind in which the imagination has got the better of the judgment” - William Warburton.