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World J Stem Cells. Feb 26, 2024; 16(2): 137-150
Published online Feb 26, 2024. doi: 10.4252/wjsc.v16.i2.137
Advances in the differentiation of pluripotent stem cells into vascular cells
Yi-Chang Jiao, Ying-Xin Wang, Wen-Zhu Liu, Jing-Wen Xu, Yu-Ying Zhao, Chuan-Zhu Yan, Fu-Chen Liu
Yi-Chang Jiao, Ying-Xin Wang, Wen-Zhu Liu, Jing-Wen Xu, Yu-Ying Zhao, Chuan-Zhu Yan, Fu-Chen Liu, Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Yi-Chang Jiao, Ying-Xin Wang, Wen-Zhu Liu, Jing-Wen Xu, Yu-Ying Zhao, Chuan-Zhu Yan, Fu-Chen Liu, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Chuan-Zhu Yan, Mitochondrial Medicine Laboratory, Qilu Hospital (Qingdao) of Shandong University, Qingdao 266103, Shandong Province, China
Chuan-Zhu Yan, Fu-Chen Liu, Brain Science Research Institute, Shandong University, Jinan 250012, Shandong Province, China
Co-corresponding authors: Chuan-Zhu Yan and Fu-Chen Liu.
Author contributions: Jiao YC wrote the manuscript and designed the figures; Wang YX and Liu WZ collected the references; Xu JW provided the input in writing the paper; Zhao YY modified the manuscript; Yan CZ and Liu FC designed the manuscript and approved the final manuscript for publication; and all authors read and approved the final manuscript. Yan CZ and Liu FC contributed equally to this work. The choice of these researchers as co-corresponding authors acknowledges and respects this equal contribution, while recognizing the spirit of teamwork and collaboration of this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fu-Chen Liu, MD, PhD, Professor, Department of Neurology, Qilu Hospital of Shandong University, No. 107 West Wenhua Road, Jinan 250012, Shandong Province, China. fuchen.liu@email.sdu.edu.cn
Received: November 21, 2023
Peer-review started: November 21, 2023
First decision: December 6, 2023
Revised: December 20, 2023
Accepted: January 16, 2024
Article in press: January 16, 2024
Published online: February 26, 2024
Core Tip

Core Tip: Blood vessels play crucial physiological roles and are closely related to many human diseases. Although mouse or rats have been widely used in current biomedical studies, human specific-vascular bio- and patho-physiology are hardly to recapitulate because of the species differences between human and animals. The rise of induced pluripotent stem cells (iPSCs) provides a reliable method. Until now, iPSC technology and its differentiation into vascular cells or organoids provide valuable tools for studies of vascular diseases in the fields of disease modeling, drug development, regenerative medicine and gene manipulation.