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World J Stem Cells. Oct 26, 2022; 14(10): 744-755
Published online Oct 26, 2022. doi: 10.4252/wjsc.v14.i10.744
Therapeutic applications of adipose-derived stromal vascular fractions in osteoarthritis
Qi Tang, Xian-Sheng Zhao, Ao Guo, Ruo-Tong Cui, Huai-Le Song, Zi-Yang Qi, Yi Pan, Yue Yang, Fang-Fang Zhang, Liang Jin
Qi Tang, Ao Guo, Ruo-Tong Cui, Huai-Le Song, Zi-Yang Qi, Yi Pan, Yue Yang, Fang-Fang Zhang, Liang Jin, School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, China
Xian-Sheng Zhao, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China
Author contributions: Tang Q and Zhao XS contributed data collection and manuscript writing; Guo A, Cui RT, Song HL, Qi ZY, Pan Y, Yang Y contributed data analysis; Zhang FF, Jin L contributed study design and supervision; all authors have read and approve the final manuscript.
Supported by National Natural Science Foundation of China, No. 82070801, No. 82100858, No. 82073227; China Postdoctoral Science Foundation, No. 2020M671661; Jiangsu Province Science Foundation for Youths, No. BK20200569; and Jiangsu Province Research Founding for Postdoctoral, No. 1412000016.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Liang Jin, PhD, Professor, School of Life Science and Technology, China Pharmaceutical University, No. 24 Tongjiaxiang Avenue, Nanjing 211198, Jiangsu Province, China. ljstemcell@cpu.edu.cn
Received: April 6, 2022
Peer-review started: April 6, 2022
First decision: June 22, 2022
Revised: July 8, 2022
Accepted: September 12, 2022
Article in press: September 12, 2022
Published online: October 26, 2022
Core Tip

Core Tip: Osteoarthritis (OA) is one of the world's leading causes of disability. Clinically, palliative drugs cannot fundamentally cure this disease. The stromal vascular fraction (SVF) from adipose tissues is a heterogeneous cell population. According to studies, it contains a large number of mesenchymal stem cells, which have been used to treat OA with good therapeutic effects. In this review, we present an updated status of the comprehensive and systematic review of pathogenesis, diagnosis, and current clinical treatments for OA, especially focusing on therapeutic applications of adipose-derived SVF.