Why stem/progenitor cells lose their regenerative potential

doi:10.4252/wjsc.v13.i11.1714

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Nov 26, 2021 (publication date) through May 21, 2024

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Nov 26, 2021; 13(11): 1714-1732
Published online Nov 26, 2021. doi: 10.4252/wjsc.v13.i11.1714

Why stem/progenitor cells lose their regenerative potential

Angela Picerno, Alessandra Stasi, Rossana Franzin, Claudia Curci, Ighli di Bari, Loreto Gesualdo, Fabio Sallustio

Angela Picerno, Alessandra Stasi, Rossana Franzin, Claudia Curci, Ighli di Bari, Loreto Gesualdo, Department of Emergency and Organ Transplantation, University of Bari “Aldo Moro”, Bari 70124, Italy

Fabio Sallustio, Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, Bari 70124, Italy

Author contributions: Picerno A, Stasi A, Franzin R, Curci C, di Bari I, Gesualdo L and Sallustio F collected the data and contributed to the writing of the manuscript; Sallustio F and Picerno A devised the project, developed the main conceptual ideas and edited the manuscript; all authors revised and approved the final version.

Conflict-of-interest statement: None of the authors have any conflicts of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Fabio Sallustio, PhD, Assistant Professor, Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, 11, Bari 70124, Italy. fabio.sallustio@uniba.it

Received: March 26, 2021
Peer-review started: March 26, 2021
First decision: May 12, 2021
Revised: May 26, 2021
Accepted: October 31, 2021
Article in press: October 31, 2021
Published online: November 26, 2021

Core Tip

Core Tip: Aging influences the ability of stem cell renewal, inducing a gradual functional decline of adult tissue-specific stem cells in maintaining homeostasis of the tissue and playing a role in the pathophysiology of various aging-associated disorders. Stem cell rejuvenation strategies may reverse this aging phenotype.