Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2019; 11(9): 618-633
Published online Sep 26, 2019. doi: 10.4252/wjsc.v11.i9.618
Published online Sep 26, 2019. doi: 10.4252/wjsc.v11.i9.618
Cell membrane and bioactive factors derived from mesenchymal stromal cells: Cell-free based therapy for inflammatory bowel diseases
Fabiany da Costa Gonçalves, Nephrology and Transplantation, Internal Medicine, Erasmus Medical Center, Rotterdam, GD 3015, Netherlands
Ana Helena Paz, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035-903, Brazil
Author contributions: All authors equally contributed to this paper.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Fabiany da Costa Gonçalves, PhD, Postdoctoral Fellow, Nephrology and Transplantation, Internal Medicine, Erasmus Medical Center, Doctor Molewaterplein 40, Rotterdam, GD 3015, Netherlands. fabygon85@gmail.com
Telephone: +31-10-7035421
Received: March 4, 2019
Peer-review started: March 4, 2019
First decision: April 11, 2019
Revised: March 23, 2019
Accepted: July 16, 2019
Article in press: July 16, 2019
Published online: September 26, 2019
Peer-review started: March 4, 2019
First decision: April 11, 2019
Revised: March 23, 2019
Accepted: July 16, 2019
Article in press: July 16, 2019
Published online: September 26, 2019
Core Tip
Core tip: Recent experimental studies have suggested that both bioactive factors and surface proteins of mesenchymal stem cells demonstrate great therapeutic potential for overcoming the deficiencies of current therapies for inflammatory bowel diseases. Our goal in this review is to describe cell-free therapy based upon the therapeutic potential of mesenchymal stem cells, while avoiding the practical issues associated with the use of living cells.