Impact of a colorectal cancer screening program implantation on delays and prognosis of non-screening detected colorectal cancer

Table 1 Characteristics of the patients included

	Pre-implantation cohort (n = 322)	Post-implantation cohort (n = 285)	P value1
Sex			0.1
Male	184 (57.1%)	178 (62.5%)
Female	138 (42.9%)	107 (37.5%)
Age (yr)	74.1 ± 11.8	74.8 ± 11.1	0.4
Colorectal location			0.8
Distal to splenic	221 (68.6%)	197 (69.1%)
Proximal to splenic	101 (31.4%)	88 (30.9%)
TNM
I	45 (14.0%)	47 (16.5%)
II	93 (26.9%)	71 (24.9%)
III	101 (31.4%)	99 (34.7%)	0.5
IV	65 (20.2%)	57 (20.0%)
Unknown	18 (5.6%)	11 (3.9%)
Rural/Urban
Rural	218 (67.9%)	195 (68.4%)	0.8
Urban	103 (32.1%)	90 (31.6%)
Initial consultation
Primary healthcare	281 (87.3%)	241 (84.6%)
Secondar y healthcare	33 (10.2%)	37 (13.0%)	0.5
Emergency department	8 (2.5%)	7 (2.5%)
Hospitalization
Yes	135 (41.9%)	114 (40.0%)	0.6
No	187 (52.2%)	171 (60.0%)
Colonoscopy request
Primary healthcare	82 (25.5%)	102 (35.8%)
Secondary healthcare			0.04
After referral	160 (49.7%)	116 (40.7%)
Direct request	45 (14.0%)	40 (14.0%)
No colonoscopy	35 (10.9%)	27 (9.5%)

¹Statistical significance in the univariate analysis using the Chi-square test for qualitative variables and the Student t test for quantitative variables.

Table 2 Delay to colorectal cancer diagnosis in the pre and post-implantation cohorts

	Pre-implantation cohort (n = 322)	Post-implantation cohort (n = 285)	P value1
Global diagnostic delay (d)	106.64 ± 148.84	82.84 ± 109.31	0.02
Primary healthcare delay (d)	35.88 ± 84.47	39.28 ± 98.03	0.7
Referral delay (d)	13.18 ± 25.77	16.02 ± 41.63	0.4
Secondary healthcare delay (d)	46.01 ± 111.65	29.20 ± 60.83	0.02
Colonoscopy delay (d)	43.71 ± 78.22	37.75 ± 53.37	0.3

¹Statistical significance in the univariate analysis using the Student t test.

Table 3 Factors associated with survival

	Hazard ratio1 (95%CI)
Sex
Male	1
Female	1.18 (0.89-1.58)
Age (yr)	1.06 (1.04-1.07)
Colorectal location
Distal to splenic	1
Proximal to splenic	0.84 (0.62-1.13)
Cohort
Pre-implantation	1
Post-implantation	1.12 (0.83-1.51)
TNM
I	1
II	2.17 (1.07-4.40)
III	3.07 (1.56-6.08)
IV	19.22 (9.86-37.44)
Unknown	9.24 (4.27-19.99)
Initial consultation
Primary healthcare	1
Secondary healthcare	2.93 (1.01-8.55)
Emergency department	2.06 (0.67-6.34)
Hospitalization
Yes	1.67 (1.17-2.38)
No	1
Colonoscopy request
Primary healthcare	1.79 (0.96-3.35)
Secondary healthcare	1.54 (0.92-2.58)
After referral from Primary Healthcare	0.74 (0.25-2.21)
Direct request	1
No colonoscopy
Rural/Urban
Rural	1
Urban	1.44 (1.06-1.98)
Diagnostic delay (d)	1.001 (1.00-1.002)

¹Hazard Ratio and its 95% confidence interval calculated using a multivariate proportional hazard regression analysis.