Copyright
©The Author(s) 2017.
World J Gastroenterol. Jan 7, 2017; 23(1): 110-120
Published online Jan 7, 2017. doi: 10.3748/wjg.v23.i1.110
Published online Jan 7, 2017. doi: 10.3748/wjg.v23.i1.110
Table 1 TFF1, TFF3, and TWIST1 expression in different colorectal cancer tissues n (%)
| Histology | n | TFF1 | TFF3 | TWIST1 | |||||||||
| - | + | ++ | +++ | - | + | ++ | +++ | - | + | ++ | +++ | ||
| CRC | 75 | 25 (41) | 19 (35.8) | 23 (67.6) | 8 (57.1) | 16 (72.7) | 34 (55.7) | 21 (38.9) | 4 (16) | 34 (34.7) | 18 (56.3) | 16 (64) | 7 (100) |
| MNT | 47 | 34 (55.7) | 12 (22.6) | 1 (2.9) | 0 | 0 | 8 (13.1) | 22 (40.7) | 17 (68) | 39 (41.9) | 7 (21.9) | 1 (4.3) | 0 |
| MLN | 30 | 2 (3.3) | 17 (32.1) | 8 (23.5) | 3 (21.4) | 6 (27.3) | 14 (23) | 8 (14.8) | 2 (8) | 20 (21.7) | 5 (15.6) | 5 (21.7) | 0 |
| Liver M | 10 | 0 | 5 (9.4) | 2 (5.9) | 3 (21.4) | 0 | 5 (8.2) | 3 (5.6) | 2 (8.0) | 5 (5.4) | 2 (6.3) | 3 (13) | 0 |
| Overall | P = 0.000 | P = 0.000 | P = 0.000 | ||||||||||
Table 2 Comparison between low and high expression of TFF1, TFF3, and TWIST1 in different colorectal cancer tissues n (%)
| Histology | n | TFF1 | TFF3 | TWIST1 | ||||||
| Low | High | P value | Low | High | P value | Low | High | P value | ||
| CRC | 75 | 44 (38.6) | 31 (64.6) | 0.000 | 50 (60.2) | 25 (31.6) | 0.000 | 52 (40) | 23 (71.9) | 0.001 |
| MNT | 47 | 46 (40.4) | 1 (2.1) | 0.000 | 8 (9.6) | 39 (49.4) | 0.000 | 46 (35.4) | 1 (3.1) | 0.0001 |
| MLN | 30 | 19 (16.7) | 11 (22.9) | 0.659 | 20 (24.1) | 10 (12.7) | 0.818 | 25 (19.2) | 5 (15.6) | 0.142 |
| Liver M | 10 | 5 (4.4) | 5 (10.4) | 0.602 | 5 (6) | 5 (6.3) | 0.494 | 7 (5.4) | 3 (9.4) | 0.966 |
Table 3 Correlation among TFF1, TFF3 and TWIST1expression n (%)
| Protein expression | TFF1 | TFF3 | ||||
| Low | High | P value | Low | High | P value | |
| TWIST1 | 0.297 | 0.623 | ||||
| Low | 32 (72.7) | 19 (61.3) | 31 (66) | 20 (71.4) | ||
| High | 12 (27.3) | 12 (38.7) | 16 (34) | 8 (28.6) | ||
| TFF3 | ||||||
| Low | 22 (46.8) | 25 (53.2) | 0.007 | |||
| High | 22 (78.6) | 6 (21.4) | ||||
Table 4 Correlation between TFF1, TFF3, and TWIST1 expression and clinicopathological Characteristics of colorectal cancers n (%)
| Characteristicn = 75 | TFF1 | TFF3 | TWIST1 | ||||||
| Low | High | P value | Low | High | P value | Low | High | P value | |
| Age (yr) | 0.299 | 0.368 | 0.840 | ||||||
| ≤ 60 | 28 (63.6) | 17 (54.8) | 27 (57.4) | 18 (64.3) | 31 (60.8) | 14 (58.3) | |||
| > 60 | 16 (36.4) | 14 (45.2) | 20 (42.6) | 10 (35.7) | 20 (39.2) | 10 (41.7) | |||
| Gender | 0.369 | 0.146 | 0.134 | ||||||
| Male | 30 (68.2) | 18 (58.1) | 33 (70.2) | 15 (53.6) | 30 (58.8) | 18 (75.0) | |||
| Female | 14 (31.8) | 13 (41.9) | 14 (29.8) | 13 (46.4) | 21 (41.2) | 6 (25.0) | |||
| Histology | 0.089 | 0.475 | 0.397 | ||||||
| Adenocarcinoma | 42 (95.5) | 26 (83.9) | 42 (89.4) | 26 (92.9) | 47 (92.2) | 21 (87.5) | |||
| Mucinous | 2 (4.5) | 5 (16.1) | 5 (10.6) | 2 (7.1) | 4 (7.8) | 3 (12.5) | |||
| Differentiation | 0.029 | 0.136 | 0.234 | ||||||
| Well | 10 (22.7) | 12 (38.7) | 15 (31.9) | 7 (25.0) | 18 (35.3) | 4 (16.7) | |||
| Moderate | 16 (36.4) | 15 (48.4) | 22 (46.8) | 9 (32.1) | 20 (39.2) | 11 (45.8) | |||
| Poor | 18 (40.9) | 4 (12.9) | 10 (21.3) | 12 (42.9) | 13 (25.5) | 9 (37.5) | |||
| Location | 0.802 | 0.411 | 0.847 | ||||||
| Colon | 31 (70.5) | 21 (67.7) | 31 (66.0) | 21 (75) | 35 (68.6) | 17 (70.8) | |||
| Rectum | 13 (29.5) | 10 (32.3) | 16 (34.0) | 7 (25) | 16 (31.4) | 7 (30.7) | |||
| T | 0.545 | 0.651 | 0.246 | ||||||
| 1 | 2 (4.5) | 0 | 1 (2.1) | 1 (3.6) | 1 (2.0) | 1 (4.2) | |||
| 2 | 10 (22.7) | 9 (29.0) | 14 (29.8) | 5 (17.9) | 16 (31.4) | 3 (12.5) | |||
| 3 | 13 (29.5) | 7 (22.6) | 11 (23.4) | 9 (32.1) | 11 (21.6) | 9 (37.5) | |||
| 4 | 19 (43.2) | 15 (48.4) | 21 (44.7) | 13 (46.4) | 23 (45.1) | 11 (45.8) | |||
| N | 0.143 | 0.034 | 0.000 | ||||||
| No | 26 (59.1) | 13 (41.9) | 20 (42.6) | 19 (67.9) | 34 (66.7) | 5 (20.8) | |||
| Yes | 18 (40.9) | 18 (58.1) | 27 (57.4) | 9 (32.1) | 17 (33.3) | 19 (79.2) | |||
| M | 0.484 | 0.267 | 0.288 | ||||||
| No | 41 (93.2) | 28 (90.3) | 42 (89.4) | 27 (96.4) | 48 (94.1) | 21 (87.5) | |||
| Yes | 3 (6.8) | 3 (9.7) | 5 (10.6) | 1 (3.6) | 3 (5.9) | 3 (12.5) | |||
| Staging | 0.917 | 0.031 | 0.003 | ||||||
| I | 9 (20.5) | 6 (19.4) | 11 (23.4) | 4 (14.3) | 13 (25.5) | 2 (8.3) | |||
| II | 17 (38.6) | 10 (32.3) | 11 (23.4) | 16 (57.1) | 23 (45.1) | 4 (16.7) | |||
| III | 15 (34.1) | 12 (38.7) | 20 (42.6) | 7 (25.0) | 12 (23.5) | 15 (62.5) | |||
| IV | 3 (6.8) | 3 (9.7) | 5 (10.6) | 1 (3.6) | 3 (5.9) | 3 (12.5) | |||
Table 5 Significant predictive factors for cancer-specific survival in COX proportional-hazard analysis
| Prognostic factor | Univariate HR (95%CI) | P value | Multivariate HR (95%CI) | P value |
| Age | 0.404 (0.189-0.864) | 0.019 | 0.262 (0.106-0.647) | 0.004 |
| Gender | 1.137 (0.565-2.287) | 0.719 | 1.065 (0.450-2.519) | 0.887 |
| Histopathological type | 0.526 (0.126-2.193) | 0.378 | 0.380 (0.080-1.809) | 0.224 |
| Tumor differentiation | 0.939 (0.611-1.445) | 0.775 | 0.701 (0.395-1.246) | 0.226 |
| T | 1.556 (1.030-2.350) | 0.036 | 0.979 (0.578-1.657) | 0.937 |
| N | 2.961 (1.954-4.485) | 0.000 | 1.668 (0.716-3.889) | 0.236 |
| M | 12.519 (4.593-34.120) | 0.000 | 2.728 (0.672-11.064) | 0.160 |
| Stage | 4.507 (2.706-7.507) | 0.000 | 2.718 (1.003-7.368) | 0.039 |
| TFF1 | 1.805 (0.929-3.509) | 0.081 | 1.539 (0.661-3.579) | 0.317 |
| TFF3 | 0.382 (0.178-0.819) | 0.013 | 0.224 (0.085-0.593) | 0.003 |
| TWIST1 | 2.819 (1.441-5.515) | 0.002 | 1.904 (0.847-4.278) | 0.119 |
- Citation: Yusup A, Huji B, Fang C, Wang F, Dadihan T, Wang HJ, Upur H. Expression of trefoil factors and TWIST1 in colorectal cancer and their correlation with metastatic potential and prognosis. World J Gastroenterol 2017; 23(1): 110-120
- URL: https://www.wjgnet.com/1007-9327/full/v23/i1/110.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i1.110