Second-look endoscopy with prophylactic hemostasis is still effective after endoscopic submucosal dissection for gastric neoplasm

Table 1 Clinical characteristics before second look endoscopy according to the rebleeding risk after endoscopic submucosal dissection n (%)

	High risk group (n = 66)	Low risk group (n = 244)	P value
Forrest classfication	Ia, Ib, IIa (21.2)	IIb, IIc, III (78.8)
	Ia (n = 0)	IIb (n = 55)
	Ib (n = 48)	IIc (n = 14)
	IIa (n = 18)	III (n = 175)
Age, mean (mean ± SD, yr)	65.2 ± 8.6	64.7 ± 9.4	0.70
Sex, male/female	43/23	150/94	0.58
Comorbidities (Charlson scale)			0.96
0	49 (74.2)	178 (73.0)
1	13 (19.7)	52 (21.3)
2	3 (4.5)	9 (3.7)
3	1 (1.5)	3 (1.2)
4	0 (0)	2 (0.8)
Use of antiplatelet or anticoagulant agents or steroid or nonsteroidal anti-inflammatory drugs			0.03
Yes	10 (15.2)	17 (7.0)
None or unknown	56 (84.8)	227 (93.0)

Table 2 Outcomes of endoscopic submucosal dissection n (%)

	High risk group (n = 66)	Low risk group (n = 244)	P value
Prodecure time (mean ± SD, min)	50.5 ± 27.6	44.2 ± 29.7	0.12
Resection type (en bloc)	66 (100.0)	244 (100.0)
Lesion location			0.004
High body, cardia	0 (0.0)	10 (4.1)
Mid body, lower body	9 (13.6)	9 (3.7)
Antrum, angle	57 (86.4)	225 (92.2)
Lesion characteristics			0.006
Elevated	54 (81.8)	227 (93.0)
Flat or depressed	12 (18.2)	17 (7.0)
Lesion size (maximum diameter)	12.0 ± 7.3	12.5 ± 8.4	0.69
Resected specimen size (maximum diameter)	32.3 ± 9.4	30.7 ± 10.8	0.25
Histologic type			0.36
Cancer	20 (30.3)	54 (22.1)
High grade dysplasia	6 (9.1)	29 (11.9)
Lower grade dysplasia	40 (60.6)	161 (66.0)
Presence of Helicobacter pylori			0.87
Yes	11 (16.7)	36 (14.8)
No	54 (81.8)	204 (83.6)
Unknown	1 (1.5)	4 (1.6)
Endoscopic hemostasis			1.00
Yes	66 (100.0)	0 (0.0)
No	0 (0.0)	244 (100.0)
Occurrence of delayed bleeding			0.38
Yes	1 (1.5)	1 (0.4)
No	65 (98.5)	243 (99.6)