Serum vitamin D3 does not correlate with liver fibrosis in chronic hepatitis C

Table 1 Characteristics of patients and controls

Features	Patients (n = 120)	Controls (n = 11)
Male/female	57/63	4/7
Age (yr)	51.33 ± 7.33	38.45 ± 6.95
BMI (kg/m2)	22.34 ± 2.73	24.00 ± 2.53
ALT (U/L)	60.42 ± 70.88	16.71 ± 5.14
AST (U/L)	47.94 ± 44.30	19.87 ± 3.49
TBIL (µmol/L)	16.51 ± 7.25	16.30 ± 5.64
DBIL (µmol/L)	3.26 ± 1.36	2.82 ± 0.75
TP (g/L)	70.93 ± 4.95	69.05 ± 3.15
ALB (g/L)	43.24 ± 2.36	43.86 ± 2.18
GGT (U/L)	22.04 ± 16.50	15.90 ± 10.82
CHE (U/L)	6657.09 ± 1442.44	7703.45 ± 945.75
Ca (mmol/L)	2.26 ± 0.08	2.21 ± 0.05
P (mmol/L)	0.92 ± 0.19	1.02 ± 0.14
HB (g/L)	151.09 ± 16.56	144.45 ± 11.43
PLT (× 109/L)	171.36 ± 53.20	242.18 ± 48.36
PTA (%)	92.41 ± 9.11	93.78 ± 4.69
Virus load, n (%)
< 4 log10	20 (16.7)
4-5 log10	52 (43.3)
6-7 log10	48 (40.0)
Stage of fibrosis, n (%)
0	1 (0.8)
1	55 (45.8)
2	50 (47.1)
3	12 (10)
4	2 (1.7)
Grade of inflammation, n (%)
0	1 (0.8)
1	16 (13.3)
2	67 (55.8)
3	34 (28.3)
4	2 (1.7)

BMI: Body Mass Index; ALT: Alanine Aminotransferase; AST: Aspartate Aminotransferase; TBIL: Total Bilirubin; DBIL: Direct Bilirubin; TP: Total Protein; ALB: Albumin; GGT: Gamma-glutamyl Transpeptidase; CHE: Cholinesterase; HB: Hemoglobin; PLT: Platelets; PTA: Prothrombin Time Activity.

Table 2 Serum 25(OH)D₃ and 24,25(OH)₂D₃ levels, and the 25(OH)D₃/24,25(OH)₂D₃ ratio, in chronic hepatitis C patients and healthy controls

	Patients(n = 120)	Controls(n = 11)	P value
25(OH)D3 (ng/mL)	5.84 ± 2.63	10.08 ± 3.15	< 0.001
24,25(OH)2D3 (ng/mL)	1.78 ± 1.02	2.30 ± 1.27	0.161
25(OH)D3/24,25(OH)2D3	4.10 ± 2.44	5.52 ± 2.47	0.076

Table 3 Correlations of serum 25(OH)D₃ and 24,25(OH)₂D₃ levels, and the 25(OH)D₃/24, 25(OH)₂D₃ ratio, with clinical parameters

	25(OH)D3 (ng/mL)		24,25(OH)2D3 (ng/mL)		25(OH)D3/24,25(OH)2D3
	r value	P value	r value	P value	r value	P value
Age (yr)	-0.034	0.711	-0.132	0.150	-0.134	0.145
ALT (U/L)	-0.062	0.502	0.175	0.055	-0.230	0.012
AST (U/L)	0.036	0.693	0.169	0.066	-0.149	0.104
TBIL (μmol/L)	-0.124	0.177	0.088	0.337	-0.176	0.054
DBIL (μmol/L)	-0.165	0.072	0.109	0.065	-0.282	0.002
TP (g/L)	-0.126	0.170	0.136	0.138	-0.185	0.043
ALB (g/L)	0.027	0.770	0.120	0.193	-0.112	0.223
GGT (U/L)	-0.143	0.119	0.104	0.260	-0.211	0.021
CHE (U/L)	-0.015	0.871	-0.058	0.526	-0.011	0.906
Ca (mmol/L)	0.027	0.768	0.200	0.028	-0.158	0.084
P (mmol/L)	0.088	0.337	-0.130	0.158	0.266	0.003
HB (g/L)	-0.040	0.665	0.133	0.149	-0.195	0.033
PTA (%)	0.109	0.237	-0.134	0.145	0.231	0.011
Liver fibrosis	-0.052	0.574	0.023	0.807	-0.072	0.435
Liver inflammation	-0.104	0.258	-0.129	0.160	0.069	0.451
Viral load( IU/mL)	0.074	0.464	0.173	0.086	-0.131	0.196
25(OH)D3 (ng/mL)	-	-	0.410	< 0.001	-	-
24,25(OH)2D3 (ng/mL)	0.410	< 0.001	-	-	-	-

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBIL: Total bilirubin; DBIL: Direct bilirubin; TP: Total protein; ALB: Albumin; GGT: Gamma-glutamyl transpeptidase; CHE: Cholinesterase; HB: Hemoglobin; PLT: Platelets; PTA: Prothrombin time activity.