Association of fucosyltransferase 2 gene variants with ulcerative colitis in Han and Uyghur patients in China

Table 1 Clinical characteristics of the study subjects

Items	Han population	Uyghur population	Total
UC patients	53	49	102
Gender (male/female)	22/31	25/24	47/55
Age of onset (yr)	52 ± 15	46 ± 15	48 ± 16
Extensive colitis	20 (0.38)	30 (0.61)	50 (0.49)
Distal colitis	33 (0.62)	19 (0.39)	52 (0.51)
Mild and moderate	47 (0.89)	40 (0.82)	87 (0.85)
Severe	6 (0.11)	9 (0.18)	15 (0.15)
Healthy controls	161	149	310
Gender (male/female)	67/94	70/79	137/173
Age of onset (yr)	48 ± 15	49 ± 13	47 ± 14

Data are shown as mean ± SD or n (%). UC: Ulcerative colitis.

Table 2 Genotypic association of four single nucleotide polymorphisms with ulcerative colitis in Han and Uyghur populations n (%)

SNPs	Allele	Groups	UC cases	Controls	χ2	P
rs281377	C/T	Han	0 (0)/6 (11.3)/47 (88.7)	9 (5.6)/42 (26.1)/110 (68.4)	9.091	0.011
	C/T	Uyghur	10 (20.4)/12 (24.5)/27 (55.1)	15 (10.1)/59 (39.6)/75 (50.3)	5.633	0.060
rs1047781	T/A	Han	5 (9.5)/13 (24.5)/35 (66.0)	19 (11.8)/61 (37.9)/81 (50.3)	4.077	0.130
	T/A	Uyghur	2 (4.0)/4 (8.2)/43 (87.8)	10 (6.7)/50 (33.6)/89 (59.7)	13.480	0.001
rs601338	A/G	Han	0 (0)/1 (1.9)/52 (98.1)	3 (1.8)/23 (14.3)/135 (83.9)	7.382	0.025
	A/G	Uyghur	6 (12.2)/9 (18.4)/34 (69.4)	20 (13.4)/76 (51.0)/53 (35.6)	18.790	8.33 × 10-5
rs602662	A/G	Han	0 (0)/3 (5.7)/50 (94.3)	0 (0)/9 (5.6)/152 (94.4)	NA	NA
	A/G	Uyghur	5 (10.2)/15 (30.6)/29 (59.2)	11 (7.4)/61 (40.9)/77 (51.7)	1.776	0.412

UC: Ulcerative colitis; SNPs: Single nucleotide polymorphisms; NA: Not available.

Table 3 Allelic association of four single nucleotide polymorphisms with ulcerative colitis in Han, Uyghur and combined populations

SNPs	Groups	Risk allele	Frequency (case/control)	χ2	Pobs	Pemp	OR (95% CI)	P (Q)	Poverall	OR (95% CI)
rs281377	Han	C	0.057/0.186	10.290	0.001	0.002	0.26 (0.11-0.63)	0.003	0.100	0.71 (0.47-1.07)
	Uyghur	C	0.327/0.299	0.270	0.603	0.636	1.14 (0.70-1.86)
rs1047781	Han	T	0.217/0.308	3.203	0.074	0.106	0.62 (0.37-1.05)	0.100	0.005	0.47 (0.31-0.72)
	Uyghur	T	0.082/0.235	10.950	0.001	0.002	0.29 (0.13-0.63)
rs601338	Han	A	0.009/0.090	7.954	0.005	0.102	0.10 (0.01-0.72)	0.140	0.0003	0.35 (0.21-0.58)
	Uyghur	A	0.214/0.389	9.979	0.002	0.002	0.43 (0.25-0.73)
rs602662	Han	A	0.028/0.028	0.000	0.985	1.000	1.01 (0.27-3.81)	0.860	0.680	0.90 (0.56-1.47)
	Uyghur	A	0.255/0.279	0.204	0.652	0.699	0.89 (0.53-1.49)

SNPs: Single nucleotide polymorphisms; Pobs: Observed P value, was calculated by 2 × 2 χ² test; Pemp: Pempirical, empirical null distribution of the association test P values; P(Q): Heterogeneity test, was calculated by Cochrane's Q test; Poverall: Meta-analysis P value, was calculated by Mantel–Haenszel test under fixed-effects or random-effects model; OR: Odd ratio; 95% CI: 95% confidential interval.