Han T, Liu Y, Liu H, Zhu ZY, Li Y, Xiao SX, Guo Z, Zhao ZG. Serum thymosin β4 levels in patients with hepatitis B virus-related liver failure. World J Gastroenterol 2010; 16(5): 625-630 [PMID: 20128033 DOI: 10.3748/wjg.v16.i5.625]
Corresponding Author of This Article
Tao Han, MD, PhD, Professor, Department of Hepatology, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cells, Tianjin Third Central Hospital, Tianjin Medical University, 83 Jintang Road, Tianjin 300170, China. hantaomd@126.com
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World J Gastroenterol. Feb 7, 2010; 16(5): 625-630 Published online Feb 7, 2010. doi: 10.3748/wjg.v16.i5.625
Table 1 Clinical characteristics of the patients [median (IQR)]
ACLF
CLF
CR
Chronic hepatitis B
Healthy subjects
n
30
31
30
32
30
Age (yr)
54 (48-61)
50 (46-55)
50 (37-55)
39 (31-45)
41 (31-49)
Gender (M:F)
23:7
21:10
20:10
26:6
20:10
ALB (g/L)
30.9 (26.3-33.2)
25.7 (22.6-28.9)
42.2 (38.4-45.7)
46.7 (42.0-49.1)
39.3 (38.1-41.1)
ALT (IU/L)
174.0 (104.3-653.0)
38.0 (27.5-49.5)
35.5 (24.0-52.8)
57.5 (25.0-75.5)
30.5 (25.1-34.7)
AST (IU/L)
274.5 (74.0-521.0)
34.0 (21.0-71.0)
19.0 (9.3-32.3)
15.0 (10.0-20.5)
23.3 (19.2-31.3)
TBIL (μmol/L)
409.7 (208.1-474.7)
170.9 (98.2-215.2)
14.3 (12.5-18.1)
15.1 (12.7-20.5)
9.7 (8.75-13.2)
CHE
2699 (1760-3286)
1586 (1129-2035)
3526 (3287-4529)
4938 (4168-5465)
6784 (6553-7463)
INR
2.29 (1.94-2.70)
2.52 (2.27-2.85
1.08 (1.01-1.13)
1.02 (1.01-1.04)
1.01 (0.95-1.02)
PLT
72.5 (44.5-104.0)
44.0 (30.5-79.0)
89.0 (78.0-99.8)
197.5 (178.0-225.0)
197.5 (187.0-222.3)
MELD
23.75 (19.81-29.55)
22.97 (19.16-27.98)
3.52 (2.39-5.23)
2.65 (1.72-4.44)
2.65 (2.05-3.70)
Child-Pugh score
11 (10-12)
12 (11-12)
6 (5-7)
5 (5-6)
5 (5-6)
Table 2 Correlation coefficients (r) and P values of thymosin β4 values vs biochemical parameters in chronic liver disease patients
Characteristics
r value
P value
ALB
0.536
< 0.001
ALT
-0.210
0.020
AST
-0.553
< 0.001
TBIL
-0.581
< 0.001
CHE
0.656
< 0.001
INR
-0.605
< 0.001
PLT
0.541
< 0.001
Child-Pugh score
-0.629
< 0.001
MELD
-0.587
< 0.001
Table 3 Comparison of thymosin β4 levels between survivors and non-survivors in liver failure group [median (IQR)]
Group
n
Survivors
Non-survivors
P value
LF
61
0.8144 (0.3979-1.1510)
0.4699 (0.2771-0.6658)
0.007
ACLF
30
0.8144 (0.4042-1.0998)
0.3656 (0.2291-0.4458)
0.016
CLF
31
0.8329 (0.4306-1.4280)
0.6581 (0.5603-0.7713)
0.317
Table 4 Median (IQR) thymosin β4 values (μg/mL) in 13 liver failure patients
Group
1 wk
2 wk
3 wk
4 wk
5 wk
Survivors
0.9402
1.2146
1.2762
1.2226
1.5486
Non-survivors
0.5458
0.6765
0.5056
0.3986
0.3488
Citation: Han T, Liu Y, Liu H, Zhu ZY, Li Y, Xiao SX, Guo Z, Zhao ZG. Serum thymosin β4 levels in patients with hepatitis B virus-related liver failure. World J Gastroenterol 2010; 16(5): 625-630