Pituitary hormone circadian rhythm alterations in cirrhosis patients with subclinical hepatic encephalopathy

Table 1 Diagnostic data on patients with cirrhosis and control patients

Cirrhosis patients		Controls
Cirrhosis etiology	Patient number	Admission diagnosis	Patient number
Alcohol	13	COPD	5
HBV infection	9	Cancer (no liver or CNS metastasis)	4
HCV infection	1	Ulcerative colitis	3
Alcohol + HBV	1	Crohn’s disease	1
Alcohol + HCV	1
Unknown	1

Table 2 Baseline biochemical data (mean± SD)

Parameter	Cirrhosis	Control	P
Bilirubin (mg/dL)	1.44 ± 0.95	0.89 ± 0.24	< 0.01
Albumin (q/dL)	4.0 ± 0.5	3.7 ± 0.9
Globulin (q/dL)	3.9 ± 0.7	3.8 ± 0.5
PT (s)	14.4 ± 1.8	11.4 ± 0.8	< 0.001
SGOT (U/L)	49 ± 31	42 ± 34

Table 3 MRI abnormalities and child scores n (%)

Child score		A5 (n = 16)	A6 (n = 6)	B7 (n = 1)	B8 (n = 2)	B9 (n = 1)	C (n = 0)
Severity of brain MRI abnormalities	0	8 (50)	-	-	-	-	-
	1	5 (31.20)	5 (83)	1 (100)	1 (50)	-	-
	2	3 (18.80)	1 (17)	-	1 (50)	1 (100)	-

MRI abnormality Grading: 0 = no abnormalities, 1 = mild abnormalities, 2 = severe abnormalities.