Use of the Crohn’s disease activity index in clinical trials of biological agents

Table 1 CDAI items and weighting factors

Item (daily sum per week)	Weighting factor
Number of liquid or very soft stools	2
Abdominal pain score in one week (rating, 0-3)	5
General well-being (rating, 1-4)	7
Sum of physical findings per week:	20
Arthritis/arthralgia
Mucocutaneous lesions (e.g. erythema nodosum, aphthous ulcers)
Iritis/uveitis
Anal disease (fissure, fistula, etc)
External fistula (enterocutaneous, vesicle, vaginal, etc)
Fever over 37.8°C
Antidiarrheal use (e.g. diphenoxylate)	30
Abdominal mass (no = 0, equivocal = 2, yes = 5)	10
47 minus hematocrit (males) or 42 minus hematocrit (females)	6
1-x (1-body weight divided by a standard weight)	1