Immunotherapy and immunoescape in colorectal cancer

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Nov 28, 2007 (publication date) through Apr 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2007; 13(44): 5822-5831
Published online Nov 28, 2007. doi: 10.3748/wjg.v13.i44.5822

Table 1 Gene transfer of immunostimulatory molecules and genetic vaccination

Cytokine	Vector	Clinical application	Mechanism	Ref.
IL-2 + IL-12	Ad	No	CTLs	10
IL-10	Retrovirus	No	CD8⁺	54
TNF-alpha	Ad	Yes	Antiangiogenic, bystander effect	75
HLA-B7/b2 microglobulin	DNA	Yes	CTLs	76
IL-12	Ad	Yes	NK, CD4⁺, CD8⁺	46
IL-12 + IL-10	Retrovirus	No	CD8⁺, CD4⁺, NK, Macrophages, Neutrophils	55
IL-2	Ad, retrovirus	Yes	CTLs	59
CCL21/LIGTH	Ad	No	DC, CD8⁺, Macrophages	61

Ad: Adenovirus; DNA: Plasmid DNA; CTLs: Cytotoxic T lymphocytes; NK: Natural killers.

Citation: Mazzolini G, Murillo O, Atorrasagasti C, Dubrot J, Tirapu I, Rizzo M, Arina A, Alfaro C, Azpilicueta A, Berasain C, Perez-Gracia JL, Gonzalez A, Melero I. Immunotherapy and immunoescape in colorectal cancer. World J Gastroenterol 2007; 13(44): 5822-5831
URL: https://www.wjgnet.com/1007-9327/full/v13/i44/5822.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i44.5822