Relationship between hepatitis B virus DNA levels and liver histology in patients with chronic hepatitis B

Table 1 HBeAg negative correlation coefficient and HBeAg positive correlation coefficient

Patientscharacteristic	HBeAgcorrelationcoefficient	NegativeP	HBeAgcorrelationcoefficient	PositiveP
Age (yr)	-0.194	0.271	0.016	0.828
History (yr)	-0.295	0.090	-0.072	0.342
Serum ALT	0.351	0.042	0.018	0.811
Serum AST	0.334	0.054	0.039	0.603
Histological grade	0.265	0.130	-0.035	0.641
Histological stage	-0.108	0.544	0.139	0.064

Table 2 Histological scores of CHB patients with respect to different HBV DNA levels

	≤ 107copies/mL (n = 14)	HBV DNA107 copies/mL< HBV DNAlevel ≤ 109copies/mL(n = 31)	Levels 109copies/mL< HBV DNAlevel ≤ 1011copies/mL(n = 145)	1011copies/mL< HBV DNAleve ≤ 1013copies/mL(n = 23)	P
Grades
Median score (range)	2 (1-3)	2 (1-3)	2 (0-4)	2 (1-3)	0.995
Stages
Median score (range)	2 (0-4)	2 (0-4)	2 (0-4)	2 (0-4)	0.187

Table 3 Comparison of demographic, clinical and virological data between HBeAg negative and positive patients mean ± SD

	HBeAg-positivepatients	HBeAg-negativepatients	P
Male: Female	136:31	37:9	0.245
Age	30 ± 9	35 ± 9	0.011
History	6 ± 4	8 ± 4	0.036
ALT (U/L)	151 ± 82	162 ± 94	0.501
AST (U/L)	98 ± 65	113 ± 103	0.418
Log 10 HBV DNA	9.8 ± 1.3	8.4 ± 1.7	0.000