Rapid Communication
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 28, 2006; 12(8): 1300-1302
Published online Feb 28, 2006. doi: 10.3748/wjg.v12.i8.1300
Table 1 Effects of emetogens on minks (n = 6, mean±SD)
EmetogensDose(mg/kg)Latency(min)Retching(n)Emesis(n)Vomitingratio
NS--000/6
Cisplatin7.592.0 ± 2191.5 ± 3712.0 ± 36/6
NS--000/6
Apomorphine1.639.4 ± 3628.5 ± 165.3 ± 1.96/6
NS--000/6
Copper sulfate407.0 ± 2.029.0 ± 98.7 ± 2.36/6
Pseudo irradiation0-000/6
X-ray18 Gy17.0 ± 419.3 ± 710.4 ± 35/6
Table 2 Effects of ondansetron or metoclopramide on emesis induced by cisplatin or apomorphine in minks (mean±SD, n=6)
EmetogensDose (mg/kg)Anti-emeticsDose (mg/kg)Latency (min)Retching (n)Emesis (n)
Cisplatin7.5NS92.0 ± 2191.5 ± 3712 ± 
Cisplatin7.5Ondansetron2143.8 ± 8047.3 ± 415.3 ± 5a
Apomorphine1.6NS39.4 ± 3628.5 ± 165.3 ± 1.9
Apomorphine1.6Metoclopramide4-a1.3 ± 3b0.3 ± 0.8d