Case Report
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 14, 2006; 12(46): 7551-7555
Published online Dec 14, 2006. doi: 10.3748/wjg.v12.i46.7551
Table 1 Patients’ laboratory values
CaseAge (yr)Use of cyproterone acetate (mo)Daily dose (mg)Bilirubin (total/direct, g/L)1AST/ALT (IU/L)2Alkaline phospatase (IU/L)3Albumin (g/L)4INR5
1821220029.5/18.4935/5353003.91.4
283730010.1/9.2721/28335042.24
378330030.0/25.3505/3203804.21.2
Table 2 CPA-induced hepatotoxicity: review of 14 cases
ReferenceAge (yr)Liver injuryDoses (mg)Latency (mo)Duration1(wk)
Levesque[1]78ALF20062
Parys[11]65ALF300127
Parys[11]83ALF300152
Bressollette[16]79ALF300102
Hirsch[14]92ALF10045
Murphy[2]73ALF1004Alive
Lombardi[15]84ALF1
Friedmann[13]81ALF30067
Friedmann[13]66ALF30024
Giordano[10]87AH300Alive
Manolakopoulos[9]76AH1507Alive
Savidou82AH20012Alive
Savidou83AH30076
Savidou78AH3003Alive
Mean79.1242.37.34
Median803006.54
SD7.481.242.3