Leptin administration exacerbates thioacetamide-induced liver fibrosis in mice

Table 1 Degree of liver fibrosis in each group of mice

Group	n	Grade of liver fibrosis
		0	I	II	III	IV	Average
Saline	6	6	0	0	0	0	0
Leptin	6	6	0	0	0	0	0
TAA	6	0	1	4	1	0	2.00bd
TAA+leptin	6	0	0	0	5	1	3.17abd

^aP<0.05 vs TAA group;

^bP<0.01 vs saline group;

^dP<0.01 vs leptin group.

Table 2 Serum ALT and AST level (mean±SD)

Group	n	ALT (U/L)	AST (U/L)
Saline	6	50.67±10.46	76.33±12.27
Leptin	6	47.50±11.78	71.67±14.39
TAA	6	205.67±27.69bd	177.50±23.65bd
TAA+leptin	6	256.17±22.50abd	234.17±27.37abd

^aP<0.05 vs TAA group;

^bP<0.01 vs saline group;

^dP<0.01 vs leptin group.

Table 3 Changes of MDA and SOD in liver tissue (mean±SD)

Group	n	SOD (U/mg pro)	MDA (nmol/mg pro)
Saline	6	81.52±11.40	1.91±0.14
Leptin	6	83.63±10.68	1.93±0.13
TAA	6	51.80±8.36b,d	2.60±0.18b,d
TAA+leptin	6	35.78±6.11a,b,d	2.97±0.19a,b,d

^aP<0.05 vs TAA group; ^bP<0.01 vs saline group; ^dP<0.01 vs leptin group.

Table 4 Level of α1(I) procollagen mRNA in relation to β-actin (mean±SD)

Group	n	Ratio
Saline	6	0.11±0.02
Leptin	6	0.13±0.02
TAA	6	0.28±0.04bd
TAA+leptin	6	0.54±0.07bdf

^bP<0.01 vs saline group;

^dP<0.01 vs leptin group;

^fP<0.01 vs TAA group.