Inactivation of PTEN is associated with increased angiogenesis and VEGF overexpression in gastric cancer

Table 1 Comparison in PTEN and VEGF expression and MVD between chronic superficial gastritis (CSG) group and gastric cancer (GC) group (mean ± SD)

Groups	n	PTEN	VEGF	MVD
CSG	24	3.13 ± 2.3	1.25 ± 1.16	29.6 ± 9.9
GC	70	1.34 ± 1.75b	2.94 ± 1.80b	48.3 ± 19.9b

^bP < 0.01 vs CSG group.

Table 2 Association of PTEN and VEGF expression and MVD with clinicopathologic profiles in gastric cancer (mean ± SD)

Variables	n	PTEN	VEGF	MVD
Age (yr)
≤ 35	22	2.64 ± 1.81	2.77 ± 1.96	46.23 ± 17.61
>35	48	0.83 ± 1.33b	3.02 ± 1.76	49.20 ± 20.05
Gender
Male	56	1.32 ± 1.69	3.00 ± 1.91	48.45 ± 20.39
Female	14	1.71 ± 1.82	2.71 ± 1.73	47.54 ± 12.72
Differentiation
Well	18	1.56 ± 1.82	3.33 ± 1.88	45.94 ± 17.08
Poor	52	1.35 ± 1.69	2.81 ± 1.86	49.07 ± 20.72
Invasion depth
T1	8	2.50 ± 1.73	1.5 ± 1.91	27.94 ± 12.1
≥ T2	62	1.26 ± 1.69a	3.13 ± 1.82a	50.9 ± 19.31b
< T3	38	1.47 ± 1.81	2.08 ± 1.20	39.6 ± 16.6
≥ T3	32	1.31 ± 1.66	3.97 ± 1.15a	58.6 ± 18.9b
LN metastasis
Positive	46	0.87 ± 1.36	3.57 ± 1.77	53.9 ± 18.2
Negative	24	2.42 ± 1.93b	1.74 ± 2.07a	37.5 ± 19.3b
TNM Stage
I + II	36	1.83 ± 1.81	2.51 ± 1.29	39.6 ± 18.3
III + IV	34	0.97 ± 1.55	3.41 ± 1.18b	57.5 ± 17.7b

^aP < 0.05,

^bP < 0.01 vs different variables.