Copyright
©The Author(s) 2004.
World J Gastroenterol. Jul 1, 2004; 10(13): 1872-1875
Published online Jul 1, 2004. doi: 10.3748/wjg.v10.i13.1872
Published online Jul 1, 2004. doi: 10.3748/wjg.v10.i13.1872
Table 1 Targeting therapy of hscFv25-mTNFα for HCC xenografts
| Tumor bulk | Tumor weight | Regression rate of | Regression rate of | Curative | ||
| (mm × mm) | (mg) | tumor bulk (%) | tumor weight (%) | effect | ||
| PBS | 1 | 9 × 5 | 119 | 0 | 0 | NR |
| 2 | 7 × 7 | 87 | 0 | 0 | NR | |
| 3 | 9 × 4 | 51 | 0 | 0 | NR | |
| 4 | 5 × 3 | 26 | 0 | 0 | NR | |
| 5 | 5 × 4 | 30 | 0 | 0 | NR | |
| hscFv25 | 1 | 0.8 × 0.5 | 2 | 99.2 | 96.8 | PR |
| -mTNFα | 2 | 2 × 3 | 10 | 81.8 | 84.0 | PR |
| 3 | 2 × 3 | 15 | 81.8 | 76.0 | PR | |
| 4 | 0 | 0 | 100 | 100 | CR | |
| 5 | 0 | 0 | 100 | 100 | CR | |
| mTNFα | 1 | 2 × 2 | 11 | 87.9 | 82.4 | PR |
| 2 | 3 × 3 | 22 | 72.7 | 64.9 | PR | |
| 3 | 2 × 4 | 5 | 75.8 | 76.0 | PR | |
| 4 | 2 × 3 | 10 | 81.8 | 84.0 | PR | |
| 5 | 2 × 3 | 10 | 81.8 | 84.0 | PR | |
- Citation: Zhang J, Liu YF, Yang SJ, Qiao Q, Cheng H, Zhang CS, Ma FC, Guo HZ. Primary targeting of recombinant Fv-immunotoxin hscFv25-mTNFα against hepatocellular carcinoma. World J Gastroenterol 2004; 10(13): 1872-1875
- URL: https://www.wjgnet.com/1007-9327/full/v10/i13/1872.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i13.1872