HBV cccDNA in patients’ sera as an indicator for HBV reactivation and an early signal of liver damage

Table 1 HBV cccDNA in patients’ hepatocytes and sera

Patients	HBV DNA in the Biopsies (copy/cell)			HBV DNA in the sera (copy/mL)
	cccDNA	HBV DNAa	HBV/cccb	cccDNA	HBV DNAc	ccc/HBVd
1	2.05	195.5	98.7	3.4 × 106	4.8 × 1010	0.01%
2	0.03	0.17	5.8	UN	6.6 × 107	— -
3	173.1	799.5	4.6	3.1 × 105	6.0 × 1010	0.001%
4	0.16	8.13	51.7	UN	1.9 × 107	— -
5	0.03	0.08	2.8	UN	5.4 × 105	— -
6	16.02	17.4	1.1	2.4 × 106	5.3 × 108	0.46%
7	18.03	3717	206	3.1 × 107	1.8 × 1011	0.02%
8	0.79	13.1	16.5	UN	2.4 × 1010	— -
9	0.05	153.3	3406	2.8 × 105	3.0 × 109	0.01%
10	2.06	16.4	8	2.7 × 106	7.5 × 108	1.77%

^aThe total HBV copies per cell in the patients’ liver biopsies; ^bThe ratio of total HBV DNA to cccDNA in the patients’ liver biopsy; ^cThe total HBV copies per mL of the patients’ sera; ^dThe ratio of cccDNA to total HBV DNA in the patients’ sera. UN, untedectable.